[Anatomo-functional state of the central retina in premature infants with intraventricular hemorrhage and retinopathy of prematurity]. / Anatomo-funktsional'noe sostoyanie tsentral'nykh otdelov setchatki u nedonoshennykh detei, perenesshikh vnutrizheludochkovye krovoizliyaniya i retinopatiyu nedonoshennykh.

OBJECTIVE: Assessment of the anatomo-functional state of the central retina in children with intraventricular hemorrhage (IVH) and retinopathy of prematurity (ROP) in the long-term period. MATERIAL AND METHODS: We examined 51 patients (102 eyes) born 25-34 weeks' of gestation (birth weight 700-2290 g), aged 8.83±3.5 years, and 18 children (36 eyes) born prematurely aged 10.8±3.2 years. The children underwent standard ophthalmologic examination, optical coherence tomography (OCT) and visual evoked potentials (VEP). RESULTS: Retinal thickness (RT) and retinal volume (RV) in the fovea of premature infants with PH and/or IVH are significantly higher than in healthy full-term infants, which correlates with lower visual acuity (p<0.05). RT and RV in the fovea has an inverse proportional relationship with gestational age (GA), (p<0.05). According to the results of VEP, moderate organic changes in the conduction tract of the visual analyzer are noted in 45% of premature infants (p<0.05). CONCLUSION: The process of macula formation is affected by many perinatal and postnatal factors, namely: GA, birth weight, ROP, hypoxic-ischemic CNS diseases, and refractive disorders.

[The modification of a nutrient medium for determining the toxigenicity of Corynebacterium diphtheriae]. / Modifikatsiia pitatel'noi sredy dlia opredeleniia toksigennosti Corynebacterium diphtheriae.

The nutrient medium has been developed on the basis of home components to determine toxigenicity of Corynebacterium diphtheriae using the biological method of diphtheria diagnosis. The advantage of the proposed nutrient medium is independence of delivers of commercial dry nutrient agar from Dagestan Research Institute of Nutrient Media.

[The effect of Aerococcus viridans--the basis of the new therapeutic-prophylactic preparation M-bacterin--on the biological properties of Staphylococcus aureus]. / Vliianie Aerococcus viridans--osnovy novogo lechebno-profilakticheskogo preparata "M-bakterina"--na biologicheskie svoistva Staphylococcus aureus.

Representatives of the normal microflora from genus Aerococcus, in particular strain Aerococcus viridans 167 isolated from breast milk are studied for their effect on biological properties of Staphylococcus aureus in vitro and in vivo. It is established that the number of viable cells of the staphylococcus cultivated in the presence of antagonists in the beef-extract agar decreases progressively with each following passage, the population dying after the seventh-eight passage. Electronograms fix deep changes in the cell ultrastructure. A degree of changes in biological properties depends on the duration of the antagonist action. The results obtained reveal one of the mechanisms of the antagonistic action of aerococci-antagonists producing hydrogen peroxide.